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Guiding large language models to predict edit sequences for molecular synthesizability optimization

Nature Machine Intelligence, Published online: 23 September 2026; doi:10.1038/s42256-026-01304-x Computational drug design often generates molecules that cannot be synthesized. Li and Lai show how large language models can predict precise structural edits to fix these molecules, outperforming tradi…

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  1. 2026-09-23 00:00 · Nature Machine Intelligence
    Guiding large language models to predict edit sequences for molecular synthesizability optimization

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