Study finds fine-tuning biomedical LLMs can erode safety guardrails

A paired audit of biomedical fine-tuned LLMs reports that domain fine-tuning can erode knowledge-centric abstention guardrails, raising safety concerns as such models proliferate.

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1. 2026-11-09 05:00 · arXiv cs.CL
   Guardrail Erosion in Domain Fine-Tuned Large Language Models: A Paired Audit of Knowledge-Centric Abstention in Biomedical LLMs