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Why we compute ACMG criteria with code and keep the LLM on a short leash

This story is from 2026-10-28. It is preserved in the archive; the latest stories are on the live feed.

We built GenomixIQ the other way round. Compute what can be computed. Use a language model only for what is left. Flag everything for a person. This post explains the split and where it still falls short. The problem in one paragraph The ACMG/AMP guideline from 2015 (Richards et al., Genetics in Me…

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  1. 2026-10-28 12:31 · DEV Community — AI
    Why we compute ACMG criteria with code and keep the LLM on a short leash

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